Species Human Entrez 5995 | Human Mouse Ensembl ENSG00000148604 | |
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Aliases RGR, RP44, Retinal G protein coupled receptor External IDs MGI: 1929473 HomoloGene: 37709 GeneCards: RGR | ||
RPE-retinal G protein-coupled receptor also known as RGR-opsin is a protein that in humans is encoded by the RGR gene.
Contents
Function
RGR-opsin is a member of the rhodopsin-like receptor subfamily of GPCR. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. RGR-opsin preferentially binds all-trans-retinal, which is the dominant form in the dark adapted retina,upon light exposure it is isomerized to 11-cis-retinal. Therefore, RGR-opsin presumably acts as a photoisomerase to convert all-trans-retinal to 11-cis-retinal, similar to retinochrome in invertebrates. 11-cis-retinal is isomerized back within rhodopsin and the iodopsins in the rods and cones of the retina. RGR-opsin is exclusively expressed in tissue close to the rods and cones, the retinal pigment epithelium (RPE) and Müller cells. RGR-opsin may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). RGR-opsin comes in different isoforms produced by alternative splicing.
Interactions
RGR-opsin has been shown to interact with KIAA1279.