Entrez 10856 | Ensembl ENSG00000183207 | |
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Aliases RUVBL2, ECP51, INO80J, REPTIN, RVB2, TIH2, TIP48, TIP49B, CGI-46, ECP-51, TAP54-beta, RuvB like AAA ATPase 2 External IDs MGI: 1342299 HomoloGene: 4856 GeneCards: RUVBL2 | ||
RuvB-like 2 (E. coli), also known as RUVBL2, is a human gene coding for a protein belonging to the AAA+ family of proteins.
Contents
Function
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. However, the evidence for whether RUVBL2 has DNA helicase activity is contradictory. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.
Interactions
RUVBL2 has been shown to interact with RuvB-like 1 and Activating transcription factor 2.
References
RUVBL2 Wikipedia(Text) CC BY-SA