Species Human Entrez 9025 | Human Mouse Ensembl ENSG00000112130 | |
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Aliases RNF8, hring finger protein 8 External IDs MGI: 1929069 HomoloGene: 2944 GeneCards: RNF8 | ||
E3 ubiquitin-protein ligase RNF8 is an enzyme that in humans is encoded by the RNF8 gene.
Contents
Function
The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as a ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Interactions
RNF8 has been shown to interact with Retinoid X receptor alpha.
References
RNF8 Wikipedia(Text) CC BY-SA