EC number 2.3.2.24 Human Mouse | Species Human Entrez 7324 | |
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Aliases UBE2E1, UBCH6, ubiquitin conjugating enzyme E2 E1 External IDs MGI: 107411 HomoloGene: 84372 GeneCards: UBE2E1 | ||
Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene.
Contents
Function
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Interactions
UBE2E1 has been shown to interact with Ataxin 1 and NEDD4.
References
UBE2E1 Wikipedia(Text) CC BY-SA