Aliases RFC1, A1 Sauce Human Mouse Ensembl ENSG00000035928 | Species Human Entrez 5981 | |
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External IDs MGI: 97891 HomoloGene: 2187 GeneCards: RFC1 | ||
Replication factor C subunit 1 is a protein that in humans is encoded by the RFC1 gene.
Contents
Function
The protein encoded by this gene is the large subunit of replication factor C, which is a five subunit DNA polymerase accessory protein. Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability.
Interactions
RFC1 has been shown to interact with:
References
RFC1 Wikipedia(Text) CC BY-SA