Species Human Entrez 5932 | Human Mouse Ensembl ENSG00000101773 | |
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Aliases RBBP8, COM1, CTIP, JWDS, RIM, SAE2, SCKL2, retinoblastoma binding protein 8, RB binding protein 8, endonuclease External IDs MGI: 2442995 HomoloGene: 28546 GeneCards: RBBP8 | ||
Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.
Contents
Function
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
Interactions
RBBP8 has been shown to interact with: