Species Human Entrez 9693 | Human Mouse Ensembl ENSG00000109756 | |
Aliases RAPGEF2, CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap GEP, Rap guanine nucleotide exchange factor 2 External IDs MGI: 2659071 HomoloGene: 35477 GeneCards: RAPGEF2 | ||
Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.
Contents
RAPGEF2 is a cyclic AMP binding protein.
Function
Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.
Interactions
RAPGEF2 has been shown to interact with RAP1A and RALGDS.
References
RAPGEF2 Wikipedia(Text) CC BY-SA