Entrez 5906 | Ensembl ENSG00000116473 | |
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Aliases RAP1A, C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21, member of RAS oncogene family External IDs MGI: 97852 HomoloGene: 2162 GeneCards: RAP1A | ||
Function
The product of this gene belongs to the family of Ras-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
Interactions
RAP1A has been shown to interact with:
References
RAP1A Wikipedia(Text) CC BY-SA