Neha Patil (Editor)

Pulmonary surfactant protein D

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Symbol
  
Surfac_D-trimer

InterPro
  
IPR015097

PDB
  
RCSB PDB; PDBe; PDBj

Pfam
  
PF09006

Pfam
  
structures

PDBsum
  
structure summary

Pulmonary surfactant protein D httpsuploadwikimediaorgwikipediacommonsthu

In molecular biology, Pulmonary surfactant protein D (SP-D) is a protein domain predominantly found in lung surfactant. This protein plays a special role; its primary task is to act as a defence protein against any pathogens that may invade the lung. It also plays a role in lubricating the lung and preventing it from collapse. It has an interesting structure as it forms a triple-helical parallel coiled coil, helps the protein to fold into a trimer.

Contents

Function

Pulmonary surfactant protein D (SP-D), has an important role in acting as a lung host defence protein. SP-D has a significant roles in immune and inflammatory regulation of the lung as it regulates of the level of surfactant in the lungs by a process named surfactant homeostasis.

Structure

SP-D is a type of lectin, more specifically they are a collagen-containing C-type (calcium dependent) lectin which are named collectins. The collectins are responsible for immune and inflammatory control. They have a very basic structure,

  • triple-helical collagen region
  • C-terminal homotrimeric lectin or carbohydrate recognition domain (CRD).
  • SP-D is actually a monomer, these monomers assist in high affinity saccharide binding. Three of the same type of monomers associate to form a homotrimer.

    References

    Pulmonary surfactant protein D Wikipedia