Porphobilinogen

Porphobilinogen (PBG) is a pyrrole involved in porphyrin metabolism.

Contents

• Porphobilinogen deaminase physiology biochemistry and organic mechanism
• Porphobilinogen synthase physiology biochemistry and organic inorganic mechanism
• References

It is generated from aminolevulinate (ALA) by the enzyme ALA dehydratase. PBG is then converted into hydroxymethyl bilane by the enzyme porphobilinogen deaminase, also known as hydroxymethylbilane synthase.

Acute intermittent porphyria causes an increase in urinary porphobilinogen.