EC number 2.7.11.21 | ExPASy NiceZyme view MetaCyc | |
In enzymology, a polo kinase (EC 2.7.11.21) is a kinase enzyme i.e. one that catalyzes the chemical reaction
ATP + a proteinThus, the two substrates of these enzymes are ATP and protein, whereas their two products are ADP and phosphoprotein.
These enzymes belong to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases).
The systematic name of this [polo[-like] kinase] enzyme class is ATP:protein phosphotransferase (spindle-pole-dependent).
Examples and other names in common use include Cdc5, Cdc5p, Plk, PLK, Plk1, Plo1, POLO kinase, polo serine-threonine kinase, polo-like kinase, polo-like kinase 1, serine/threonine-specific Drosophila kinase polo, and STK21.
These enzymes participate in 3 metabolic pathways: cell cycle, cell cycle - yeast, and progesterone-mediated oocyte maturation.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 2OGQ, 2OJS, 2OJX, 2OU7, and 2OWB.