Girish Mahajan

Polmacoxib

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Trade names  Acelex
CAS Number  301692-76-2
ChemSpider  8017569
Molar mass  361.3914 g/mol
Synonyms  CG100649
PubChem CID  9841854
UNII  IJ34D6YPAO
Polmacoxib httpsuploadwikimediaorgwikipediacommonsthu

Polmacoxib (Acelex) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis. It was developed as CG100649 and approved for use in South Korea in February 2015. It inhibits the enzymes carbonic anhydrase and COX-2. A study in healthy volunteers showed drug effects on urinary prostaglandin metabolites for both CG100649 and celecoxib that suggest a similar cardiovascular risk profile. Further work by this group developed dose-exposure relationsships of CG100649 to guide clinical development strategies.

References

Polmacoxib Wikipedia


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