Trade names Acelex CAS Number 301692-76-2 ChemSpider 8017569 Molar mass 361.3914 g/mol | Synonyms CG100649 PubChem CID 9841854 UNII IJ34D6YPAO | |
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Polmacoxib (Acelex) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis. It was developed as CG100649 and approved for use in South Korea in February 2015. It inhibits the enzymes carbonic anhydrase and COX-2. A study in healthy volunteers showed drug effects on urinary prostaglandin metabolites for both CG100649 and celecoxib that suggest a similar cardiovascular risk profile. Further work by this group developed dose-exposure relationsships of CG100649 to guide clinical development strategies.
References
Polmacoxib Wikipedia(Text) CC BY-SA