Formula C5H13O14P3 Pubchem 7339 | Molar mass 390.07 g/mol | |
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Gene music quartet using protein sequence of prps2 phosphoribosyl pyrophosphate synthetase 2
Phosphoribosyl pyrophosphate (PRPP) is a pentosephosphate.
Contents
- Gene music quartet using protein sequence of prps2 phosphoribosyl pyrophosphate synthetase 2
- Plos one crystal and em structures of human phosphoribosyl pyrophosphate synthase i prs1
- Increased PRPP
- References
It is formed from ribose 5-phosphate by the enzyme ribose-phosphate diphosphokinase.
It plays a role in transferring phospho-ribose groups in several reactions:
In de novo generation of purines, the enzyme amidophosphoribosyltransferase acts upon PRPP to create phosphoribosylamine.
Plos one crystal and em structures of human phosphoribosyl pyrophosphate synthase i prs1
Increased PRPP
Increased levels of PRPP is characterized by the overproduction and accumulation of uric acid leading to hyperuricemia and hyperuricosuria. It is one of the causes of gout.
Increased levels of PRPP are present in Lesch-Nyhan Syndrome. Decreased levels of hypoxanthine guanine phosphoribosyl transferase (HGPRT) causes this accumulation, as PRPP is a substrate used by HGPRT during purine salvage.
References
Phosphoribosyl pyrophosphate Wikipedia(Text) CC BY-SA