Alma mater Karolinska Institutet Fields Molecular biology Education Karolinska Institutet | Name Pehr Edman Doctoral advisor Eric Jorpes | |
 | ||
Born April 14, 1916
Stockholm, Sweden ( 1916-04-14 ) Nationality Swedish (1916-65)
Australian (1965-77) Institutions Rockefeller Institute of Medical Research, Princeton University, University of Lund, St. Vincent's School of Medical Research, Max-Planck-Institut of Biochemistry Known for Edman degradation, sequenator Notable awards Fellow of the Australian Academy of Science (1968)
Britannica Australia Prize (Science, 1968)
Swedish Society of Physicians and Surgeons (Gold Medal, 1971)
Fellow of the Royal Society (1974) Died March 19, 1977, Munich, Germany Residence Sweden, Australia, United States of America, Germany | ||
Pehr Victor Edman (April 14, 1916 — March 19, 1977) was a Swedish biochemist. He developed a method for sequencing proteins, the Edman degradation.
Contents
Early life
Edman was born in Stockholm, Sweden. In 1935 he started studying medicine at Karolinska Institutet, where he became interested in basic research and received a bachelor in medicine in 1938. His research was interrupted by the outbreak of World War II, where he was drafted to serve in the Swedish army. He returned to the Karolinska Institutet where he earned his doctoral degree under advice from Professor Erik Jorpes in 1946.
Developing the Edman Degradation
At the time Edman started working on Angiotensin, it was just being recognized that proteins are distinct entities with a defined molecular mass, electric charge and structure. This inspired Edman to develop a method, that could be used to determine the sequence of amino acids in the protein. In 1947 he was awarded a travel stipend to go to Rockefeller Institute of Medical Research. When he returned to Sweden in 1950 to be an Assistant Professor at the University of Lund. In 1950 he published his first paper using the method later known as Edman degradation, to determine the sequence of a protein. To his death he continued to work to improve the method to be able to determine longer stretches with smaller amounts of sample.
Late career
In 1957 he moved to Australia to be the director of St. Vincent's School of Medical Research. In 1967 he successfully developed an automated protein sequencer, called the sequenator, with his assistant Geoffrey Begg.
In 1972 he moved to the Max-Planck-Institut of Biochemistry, Martinsried near Munich. He worked with his second wife, Agnes Henschen, and she used Edman's method to sequence fibrinogen.
In 1977 Edman died of a brain tumor after a short coma.