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Paul Sigler

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Cause of death
  
arrhythmia

Occupation
  
Professor

Nationality
  
United States

Parents
  
George Sigler

Paul Sigler httpsacademictreeorgphoto006cache062128Pa

Born
  
February 19, 1934 (
1934-02-19
)
Richmond, VA

Burial place
  
Coop Prairie Cemetery, Mansfield, Arkansas

Monuments
  
Memorial plaque on Science Hill (Yale University)

Spouse(s)
  
Althea Jo Martin Sigler

Died
  
11 January 2000, New Haven, Connecticut, United States

Education
  
University of Cambridge (1964–1967)

Awards
  
Guggenheim Fellowship for Natural Sciences, US & Canada

Residence
  
New Haven, Connecticut, United States, Chicago, Illinois, United States, Washington, D.C., United States, Cambridge, United Kingdom, New York City, New York, United States, Princeton, New Jersey, United States, Buffalo, New York, United States, Richmond, Virginia, United States

Known for
  
Phospholipase A2, Tryptophan repressor

Paul B. Sigler ((1934-02-19)February 19, 1934 – January 11, 2000(2000-01-11)) was the Henry Ford II Professor of Molecular Biophysics and Biochemistry at Yale University. Major awards included membership in the National Academy of Sciences, HHMI Investigator status, and Guggenheim and Helen Hay Whitney Fellowships. He is noted for pioneering studies of Phospholipase A2 and trp repressor amongst many others.

Contents

Biography

Prior to coming to Yale, he was a professor at the University of Chicago. He received his MD from Columbia University in 1959 and his undergraduate degree from Princeton University in 1955. After briefly practicing medicine and working as a researcher for the NIH, he would go on to earn a second doctorate, a PhD, from Cambridge University at the Laboratory of Molecular Biology working under David M. Blow before moving to the University of Chicago.

Memorials

A memorial plaque is located in front of the Bass Center for Structural Bilogy on Science Hill on the campus of Yale University. Yale has a Paul Sigler Memorial Prize for undergraduate research in Molecular Biophysics & Biochemistry. Yale also has sponsored Paul Sigler memorial symposia in the past. The Agouron Institute sponsored 12 Paul Sigler fellowships between 2000 and 2006. He is buried at Coop Prairie Cemetery in Mansfield, Arkansas.

Selected Publications

  • Lambright, David G.; Sondek, John; Bohm, Andrew; Skiba, Nikolai P.; Hamm, Heidi E.; Sigler, Paul B. (1996). "The 2.0 Å crystal structure of a heterotrimeric G protein". Nature. 379 (6563): 311. doi:10.1038/379311a0. PMID 8552184. 
  • Luisi, B. F.; Xu, W. X.; Otwinowski, Z.; Freedman, L. P.; Yamamoto, K. R.; Sigler, P. B. (1991). "Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA". Nature. 352 (6335): 497. doi:10.1038/352497a0. PMID 1865905. 
  • Braig, Kerstin; Otwinowski, Zbyszek; Hegde, Rashmi; Boisvert, David C.; Joachimiak, Andrzej; Horwich, Arthur L.; Sigler, Paul B. (1994). "The crystal structure of the bacterial chaperonln GroEL at 2.8 Å". Nature. 371 (6498): 578. doi:10.1038/371578a0. PMID 7935790. 
  • Kim, Youngchang; Geiger, James. H.; Hahn, Steven; Sigler, Paul B. (1993). "Crystal structure of a yeast TBP/TATA-box complex". Nature. 365 (6446): 512. doi:10.1038/365512a0. PMID 8413604. 
  • Vinson, C.; Sigler, P.; McKnight, S. (1989). "Scissors-grip model for DNA recognition by a family of leucine zipper proteins". Science. 246 (4932): 911. doi:10.1126/science.2683088. PMID 2683088. 
  • Otwinowski, Z; Schevitz, R. W.; Zhang, R. G.; Lawson, C. L.; Joachimiak, A; Marmorstein, R. Q.; Luisi, B. F.; Sigler, P. B. (1988). "Crystal structure of trp repressor/operator complex at atomic resolution". Nature. 335 (6188): 321–9. doi:10.1038/335321a0. PMID 3419502. 
  • References

    Paul Sigler Wikipedia