
Pamela Suzette Grier was born on May 26, 1949 in Winston-Salem, North Carolina, the daughter of Gwendolyn Sylvia (née Samuels), a homemaker and nurse, and Clarence Ransom Grier, Jr., who worked as a mechanic and Technical Sergeant in the United States Air Force. She has one sister and one brother. Grier has stated that she is of mixed ancestry consisting of African-American, Hispanic, Chinese, Filipino and Cheyenne Indian heritage.

At age 6, Grier was raped by two boys when she was left unattended at her aunt's house. "It took so long to deal with the pain of that," she says, "You try to deal with it, but you never really get over it," she adds. "And not just me; my family endured so much guilt and anger that something like that happened to me."

Because of her father's military career, her family moved frequently during her childhood, to various places such as England, and eventually settled in Denver, where she attended East High School. While in Denver she appeared in a number of stage productions, and participated in beauty contests to raise money for college tuition at Metropolitan State College.

Grier moved to Los Angeles, California, in 1967, where she was initially hired as a receptionist at American International Pictures (AIP). It is believed that she was discovered by director Jack Hill, who cast her in his women in prison films The Big Doll House (1971) and The Big Bird Cage (1972).

While under contract at AIP, she became a staple of early 1970s blaxploitation movies, playing big, bold, assertive women, beginning with Jack Hill's Coffy (1973), in which she plays a nurse who seeks revenge on drug dealers. Her character was advertised in the trailer as the "baddest one-chick hit-squad that ever hit town!" The film, which was filled with sexual and violent elements typical of the genre, was a box-office hit. Grier is considered to be the first African-American female to headline an action film, as protagonists of previous blaxploitation films were males. In his review of Coffy, critic Roger Ebert praised the film for its believable female lead. He noted that Grier was an actress of "beautiful face and astonishing form" and that she possessed a kind of "physical life" missing from many other attractive actresses. Grier subsequently played similar characters in the AIP films Foxy Brown (1974), Sheba, Baby and Friday Foster, (both 1975).
With the demise of blaxploitation later in the 1970s, Grier appeared in smaller roles for many years. She acquired progressively larger character roles in the 1980s, including a druggie prostitute in Fort Apache, The Bronx (1981), a witch in Something Wicked this Way Comes (1983), and Steven Seagal's detective partner in Above the Law (1988). She had a recurring role on Miami Vice from 1985 to 1989 and made guest appearances on Martin, Night Court and The Fresh Prince of Bel Air. She had a recurring role in the TV series Crime Story between 1986 and 1988. Her role in Rocket Gibraltar (1988) was cut due to fears by the film's director, Daniel Petrie, of "repercussions from interracial love scenes". She appeared on Sinbad, Preston Chronicles, The Cosby Show, The Wayans Brothers Show, and Mad TV. In 1994, Grier appeared in Snoop Dogg's video for "Doggy Dogg World".
In the late 1990s, Grier was a cast member of the Showtime series Linc's. She appeared in 1996 in John Carpenter's Escape from L.A. and 1997 with the title role in Quentin Tarantino's Jackie Brown, films that partly paid homage to her 1970s blaxploitation movies. She was nominated for numerous awards for her work in the Tarantino film. Grier appeared on Showtime's The L Word, in which she played Kit Porter. The series ran for six seasons and ended in March 2009. Grier occasionally guest-stars in such television series as Law & Order: Special Victims Unit (where she is a recurring character).
In 2010, Grier began appearing in a recurring role on the hit science fiction series Smallville as the villain Amanda Waller, also known as White Queen, head agent of Checkmate, a covert operations agency. She recently appeared as a friend and colleague to Julia Roberts' college professor in Larry Crowne.
In 2010, Grier wrote her memoir, Foxy: My Life in Three Acts, with Andrea Cagan.
In 1998 Grier was engaged to music executive Kevin Evans, but the engagement ended in 1999. From 2000 to 2008 she dated marketing executive Peter Hempel.. She also dated basketball player Kareem Abdul-Jabbar, comics Freddie Prinze, Richard Pryor, and Soul Train host, Don Cornelius. She also had a brief relationship with basketball player Wilt Chamberlain.
She received her Honorary Doctorate of Humane Letters from the University of Maryland Eastern Shore in 2011. That same year, she received an Honorary Doctorate of Science from Langston University. She started the Pam Grier Community Garden and Education Center with the National Multicultural Western Heritage Museum. She lives in Colorado.
"Long Time Woman" (1971, from the film The Big Doll House)
"Communication" by Bobby Womack (1971, backing vocals)
"Understanding" by Bobby Womack (1972, backing vocals)