Species Human Entrez 5798 | Human Mouse Ensembl ENSG00000054356 | |
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Aliases PTPRN, IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N, protein tyrosine phosphatase, receptor type N External IDs MGI: 102765 HomoloGene: 48142 GeneCards: PTPRN | ||
Receptor-type tyrosine-protein phosphatase-like N is an enzyme that in humans is encoded by the PTPRN gene.
Contents
Function
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family and PTPRN subfamily. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.
Interactions
PTPRN has been shown to interact with SPTBN4.