Entrez 5795 | Ensembl ENSG00000149177 | |
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Aliases PTPRJ, CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1, protein tyrosine phosphatase, receptor type J External IDs MGI: 104574 HomoloGene: 2130 GeneCards: PTPRJ | ||
Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the PTPRJ gene.
Contents
Function
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction.
Interactions
PTPRJ has been shown to interact with CTNND1.