Supriya Ghosh (Editor)

PTPRG

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Species
  
Entrez
  
5793

Human
  
Ensembl
  
ENSG00000144724

PTPRG

Aliases
  
PTPRG, HPTPG, PTPG, R-PTP-GAMMA, RPTPG, protein tyrosine phosphatase, receptor type G

External IDs
  
MGI: 97814 HomoloGene: 2129 GeneCards: PTPRG

Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.

References

PTPRG Wikipedia


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