Species Human Entrez 25865 | Human Mouse Ensembl ENSG00000105287 | |
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Aliases PRKD2, PKD2, nPKC-D2, HSPC187, protein kinase D2 External IDs MGI: 2141917 HomoloGene: 9516 GeneCards: PRKD2 | ||
Serine/threonine-protein kinase D2 or PKD2 is an enzyme that in humans is encoded by the PRKD2 gene.
Function
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases, a subfamily of protein kinase c. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.
References
PRKD2 Wikipedia(Text) CC BY-SA