Neha Patil (Editor)

PRKCQ

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Species
  
Entrez
  
5588

Human
  
Ensembl
  
ENSG00000065675

PRKCQ

Aliases
  
PRKCQ, PRKCT, nPKC-theta, protein kinase C theta

External IDs
  
MGI: 97601 HomoloGene: 21263 GeneCards: PRKCQ

Protein kinase C theta (PKC-θ) is an enzyme that in humans is encoded by the PRKCQ gene.

Contents

Function

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.

Interactions

PRKCQ has been shown to interact with:

  • AKT1
  • FYN,
  • GLRX3, and
  • VAV1.
  • PRKCQ has been shown to phosphorylate CARD11 as part of the NF-κB signaling pathway.

    Inhibitors

  • (R)-2-((S)-4-(3-Chloro-5-fluoro-6-(1H-pyrazolo[3,4-b]pyridin- 3-yl)pyridin-2-yl)piperazin-2-yl)-3-methylbutan-2-ol
  • References

    PRKCQ Wikipedia


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