Species Human Entrez 5588 | Human Mouse Ensembl ENSG00000065675 | |
 | ||
Aliases PRKCQ, PRKCT, nPKC-theta, protein kinase C theta External IDs MGI: 97601 HomoloGene: 21263 GeneCards: PRKCQ | ||
Protein kinase C theta (PKC-θ) is an enzyme that in humans is encoded by the PRKCQ gene.
Contents
Function
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
Interactions
PRKCQ has been shown to interact with:
PRKCQ has been shown to phosphorylate CARD11 as part of the NF-κB signaling pathway.