Species Human Entrez 7409 | Human Mouse Ensembl ENSG00000141968 | |
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Aliases VAV1, VAV, vav guanine nucleotide exchange factor 1 External IDs MGI: 98923 HomoloGene: 3961 GeneCards: VAV1 | ||
Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene.
Contents
Function
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
Interactions
VAV1 has been shown to interact with:
References
VAV1 Wikipedia(Text) CC BY-SA