Entrez 5434 | Ensembl ENSG00000099817 | |
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Aliases POLR2E, RPABC1, RPB5, XAP4, hRPB25, hsRPB5, polymerase (RNA) II subunit E External IDs MGI: 1913670 HomoloGene: 2018 GeneCards: POLR2E | ||
Gene music using protein sequence of polr2e polymerase rna ii dna directed polypeptide e 25kd
DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene.
Contents
- Gene music using protein sequence of polr2e polymerase rna ii dna directed polypeptide e 25kd
- Interactions
- References
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.
Interactions
POLR2E has been shown to interact with TAF15, POLR2C, POLR2G, POLR2H, POLR2A, POLR2B, POLR2L and GTF2F2.