Species Human Entrez 5358 | Human Mouse Ensembl ENSG00000102024 | |
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Aliases PLS3, BMND18, T-plastin, plastin 3 External IDs MGI: 104807 HomoloGene: 128200 GeneCards: PLS3 | ||
Plastin-3 is a highly conserved protein that in humans is encoded by the PLS3 gene on the X chromosome.
Contents
Function
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N-terminus.
Clinical significance
Defects in PLS3 are associated with osteoporosis and bone fracture in humans and in knockout zebrafish.