Species Human Entrez 9463 | Human Mouse Ensembl ENSG00000100151 | |
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Aliases PICK1, PICK, PRKCABP, protein interacting with PRKCA 1 External IDs MGI: 894645 HomoloGene: 7470 GeneCards: PICK1 | ||
Protein Interacting with C Kinase - 1 is a protein that in humans is encoded by the PICK1 gene.
Contents
Function
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.
Interactions
PICK1 has been shown to interact with: