Species Human Entrez 1912 | Human Mouse Ensembl ENSG00000134686 | |
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Aliases PHC2, EDR2, HPH2, PH2, polyhomeotic homolog 2 External IDs MGI: 1860454 HomoloGene: 75090 GeneCards: PHC2 | ||
Polyhomeotic-like protein 2 is a protein that in humans is encoded by the PHC2 gene.
Contents
Function
In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.
Interactions
PHC2 has been shown to interact with MAPKAPK2, PHC1, BMI1 and MCRS1.
References
PHC2 Wikipedia(Text) CC BY-SA