Entrez 9261 | Ensembl ENSG00000162889 | |
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Aliases MAPKAPK2, MAPKAP-K2, MK-2, MK2, mitogen-activated protein kinase-activated protein kinase 2 External IDs MGI: 109298 HomoloGene: 56412 GeneCards: MAPKAPK2 | ||
MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene.
Contents
Function
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
Interactions
MAPKAPK2 has been shown to interact with:
References
MAPKAPK2 Wikipedia(Text) CC BY-SA