Species Human Entrez 5105 | Human Mouse Ensembl ENSG00000124253 | |
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Aliases PCK1, PEPCK-C, PEPEPCKC, phosphoenolpyruvate carboxykinase 1 External IDs MGI: 97501 HomoloGene: 1944 GeneCards: PCK1 | ||
Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.
Contents
Function
This enzyme is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein also has been characterized.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.
References
PCK1 Wikipedia(Text) CC BY-SA