Species Human Entrez 22976 | Human Mouse Ensembl ENSG00000157212 | |
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Aliases PAXIP1, CAGF29, PACIP1, PAXIP1L, PTIP, TNRC2, CAGF28, PAX interacting protein 1 External IDs HomoloGene: 133914 GeneCards: PAXIP1 | ||
PAX-interacting protein 1 is a protein that in humans is encoded by the PAXIP1 gene.
Contents
Function
This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. Protein-affecting variants have also been implicated in Alzheimer's disease.
Interactions
PAXIP1 has been shown to interact with PAX2 and TP53BP1.
References
PAXIP1 Wikipedia(Text) CC BY-SA