Entrez 50855 | Ensembl ENSG00000102981 | |
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Aliases PARD6A, PAR-6A, PAR6, PAR6C, PAR6alpha, TAX40, TIP-40, par-6 family cell polarity regulator alpha External IDs MGI: 1927223 HomoloGene: 9661 GeneCards: PARD6A | ||
Partitioning defective 6 homolog alpha is a protein that in humans is encoded by the PARD6A gene.
Contents
Function
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Interactions
PARD6A has been shown to interact with:
References
PARD6A Wikipedia(Text) CC BY-SA