Puneet Varma (Editor)

PARD3

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Species
  
Human

Entrez
  
56288

Human
  
Mouse

Ensembl
  
ENSG00000148498

PARD3

Aliases
  
PARD3, ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, par-3 family cell polarity regulator

External IDs
  
MGI: 2135608 HomoloGene: 10489 GeneCards: PARD3

Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene.

Contents

Function

PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins (GAPs; see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.[supplied by OMIM]

Interactions

PARD3 has been shown to interact with:

  • JAM2,
  • JAM3,
  • PRKCI, and
  • PVRL3.

    • References

    PARD3 Wikipedia
    (Text) CC BY-SA


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