Species Human Entrez 56288 | Human Mouse Ensembl ENSG00000148498 | |
 | ||
Aliases PARD3, ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, par-3 family cell polarity regulator External IDs MGI: 2135608 HomoloGene: 10489 GeneCards: PARD3 | ||
Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene.
Contents
Function
PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins (GAPs; see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.[supplied by OMIM]
Interactions
PARD3 has been shown to interact with:
References
PARD3 Wikipedia(Text) CC BY-SA