Species Human Entrez 5036 | Human Mouse Ensembl ENSG00000170515 | |
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Aliases PA2G4, EBP1, HG4-1, p38-2G4, proliferation-associated 2G4 External IDs MGI: 894684 HomoloGene: 4513 GeneCards: PA2G4 | ||
Gene music using protein sequence of pa2g4 proliferation associated 2g4
Proliferation-associated protein 2G4 (PA2G4) also known as ErbB3-binding protein 1 (EBP1) is a protein that in humans is encoded by the PA2G4 gene.
Contents
Function
This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional corepressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.
Interactions
PA2G4 has been shown to interact with ERBB3, retinoblastoma protein, and androgen receptor.