O sialoglycoprotein endopeptidase

O-sialoglycoprotein endopeptidase (EC 3.4.24.57, glycoprotease, glycophorin A proteinase, glycoproteinase, sialoglycoprotease, sialoglycoproteinase, "OSGE") is an enzyme. This enzyme catalyses the following chemical reaction

Hydrolysis of O-sialoglycoproteins; cleaves -Arg³¹-Asp- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated

This enzyme is secreted by the bacterium Pasteurella haemolytica.