Samiksha Jaiswal (Editor)

Glycophorin

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Covid-19
Symbol  Glycophorin_A
InterPro  IPR001195
SCOP  1afo
Pfam  PF01102
PROSITE  PDOC00281
SUPERFAMILY  1afo
Glycophorin

A glycophorin is a sialoglycoprotein of the membrane of a red blood cell. It is a membrane-spanning protein and carries sugar molecules. It is heavily glycosylated (60%). Glycophorins are rich in sialic acid, which gives the red blood cells a very hydrophilic-charged coat. This enables them to circulate without adhering to other cells or vessel walls.

Contents

Identification

After separation of red cell membranes by SDS-polyacrylamide gel electrophoresis and staining with periodic acid-Schiff staining (PAS), four glycophorins have been identified. These have been named glycophorin A, B, C, and D in order of the quantity present in the membrane, gylycophorin A being the most and glycophorin D the least common. A fifth (glycophorin E) has been identified within the human genome but cannot easily be detected on routine gel staining. In total, the glycophorins constitute ~2% of the total erythrocyte membrane protein mass. These proteins are also known under different nomenclatures but they are probably best known as the glycophorins.

Family members

The following four human genes encode glycophorin proteins:

  • Glycophorin A
  • Glycophorin B
  • Glycophorin C
  • Glycophorin E
  • Glycophorin D is now known to be a variant of Glycophorin C.

    References

    Glycophorin Wikipedia


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