Species Human Entrez 79902 | Human Mouse Ensembl ENSG00000125450 | |
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Aliases NUP85, Nup75, FROUNT, nucleoporin 85 External IDs MGI: 3046173 HomoloGene: 11755 GeneCards: NUP85 | ||
Nucleoporin 85 (Nup85) is a protein that in humans is encoded by the NUP85 gene.
Contents
Function
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160.
Model organisms
Model organisms have been used in the study of NUP85 function. A conditional knockout mouse line called Nup85tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping
References
Nucleoporin 85 Wikipedia(Text) CC BY-SA