Entrez 9611 | Ensembl ENSG00000141027 | |
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External IDs MGI: 1349717 HomoloGene: 38166 GeneCards: NCOR1 | ||
The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the NCOR1 gene.
Contents
NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of gene expression.
Loss of function of this protein significantly increases the strength and power of mouse muscles.
Family
It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 2.
Interactions
Nuclear receptor co-repressor 1 has been shown to interact with: