Species Human Entrez 653361 | Human Mouse Ensembl ENSG00000158517 | |
 | ||
Aliases NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox, Neutrophil cytosolic factor 1 External IDs MGI: 97283 HomoloGene: 30964 GeneCards: NCF1 | ||
Gene music using protein sequence of ncf1 neutrophil cytosolic factor 1
Neutrophil cytosol factor 1, also known as p47phox, is a protein that in humans is encoded by the NCF1 gene.
Contents
Function
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.
Genetic variability in the NCF! gene has been found to be related to a higher chance of getting autoimmune diseases such as Sjögren's syndrome, rheumatoid arthritis and lupus erythematosus.
Interactions
Neutrophil cytosolic factor 1 has been shown to interact with:
References
Neutrophil cytosolic factor 1 Wikipedia(Text) CC BY-SA