Samiksha Jaiswal (Editor)

NOX4

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Species
  
Human

Entrez
  
50507

Human
  
Mouse

Ensembl
  
ENSG00000086991

NOX4 Frontiers From form to function the role of Nox4 in the

Aliases
  
NOX4, KOX, KOX-1, RENOX, NADPH oxidase 4

External IDs
  
MGI: 1354184 HomoloGene: 41065 GeneCards: NOX4

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NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases.

Contents

NOX4 Nox4 and p22phoxdependent signaling pathways implicated in

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Function

NOX4 Pharmacological inhibition of TLR4NOX4 signal protects against

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. Nox4 protects the vasculature against inflammatory stress. Nox-dependent reactive oxygen species modulation by amino endoperoxides can induce apoptosis in high Nox4-expressing cancer cells.

NOX4 NADPH oxidase 4 Nox4 inhibition prevents RyR1 oxidation and


NOX4 circresahajournalsorgcontentcircresaha11091

NOX4 Nox4 Is a Protective Reactive Oxygen Species Generating Vascular

References

NOX4 Wikipedia
(Text) CC BY-SA