Species Human Entrez 4801 | Human Mouse Ensembl ENSG00000120837 | |
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Aliases NFYB, CBF-A, CBF-B, HAP3, NF-YB, nuclear transcription factor Y subunit beta External IDs MGI: 97317 HomoloGene: 38149 GeneCards: NFYB | ||
Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.
Contents
Function
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.
Interactions
NFYB has been shown to interact with:
References
NFYB Wikipedia(Text) CC BY-SA