Entrez 10403 | Ensembl ENSG00000080986 | |
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Aliases NDC80, HEC, HEC1, HsHec1, KNTC2, TID3, hskinetochore complex component External IDs MGI: 1914302 HomoloGene: 38141 GeneCards: NDC80 | ||
Function
HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.[supplied by OMIM]
Interactions
NDC80 has been shown to interact with MIS12, NEK2 and PSMC2.
References
NDC80 Wikipedia(Text) CC BY-SA