N methyl 2 oxoglutaramate hydrolase

In enzymology, a N-methyl-2-oxoglutaramate hydrolase (EC 3.5.1.36) is an enzyme that catalyzes the chemical reaction

N-methyl-2-oxoglutaramate + H₂O ⇌ 2-oxoglutarate + methylamine

Thus, the two substrates of this enzyme are N-methyl-2-oxoglutaramate and H₂O, whereas its two products are 2-oxoglutarate and methylamine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-methyl-2-oxoglutaramate methylamidohydrolase. This enzyme is also called 5-hydroxy-N-methylpyroglutamate synthase.