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Mycosubtilin is a natural lipopeptide with antifungal and hemolytic activities and isolated from Bacillus species. It belongs to the iturin lipopeptide family.
Contents
Definition
Mycosubtilin is a natural lipopeptide. It is produced by the strains of Bacillus spp mainly by Bacillus subtilis. It was discovered due to its antifungal activities. It belongs to the family of iturin lipopeptides
Structure
Mycosubtilin is a heptapeptide, cyclized in a ring with a β-amino fatty acid. The peptide sequence is composed of L-Asn-D-Tyr-D-Asn-L-Gln-L-Pro-D-Ser-L-Asn. The ramification of the β-amino fatty acid can be iso or anteiso . It could contain 16-17 carbon atom.
Biological activities
Mycosubtilin has strong antifungal and hemolytic activities. It is active against fungi and yeasts such as Candida albicans, Candida tropicalis, Saccharomyces cerevisiae, Penicillium notatum, Fusarium oxysporum. Its antibacterial activity is quite limited to bacterias such as Microccocus luteus.