Bloodgood was born in Alliance, Nebraska, on September 20, 1975, but was raised in Anaheim, California. Her father, Shell Bloodgood, is an American of Dutch and Irish descent, and her mother, Sang Cha, is Korean. Her father was stationed in South Korea, where he met her mother.
At age 17, Bloodgood became one of the Laker Girls.
In 2005, she was ranked #99 on Maxim's magazine's Hot 100 list. She subsequently ranked #53 in 2006, #40 in 2007 and #20 in 2009.
In Day Break (2006–2007), she portrayed Rita Shelten, the girlfriend of a detective who is framed for murder and arrested in the span of a day, but continually finds himself reliving that same day. In 2007, Bloodgood starred as Livia Beale in the American science-fiction television series Journeyman on NBC.
She had a role in the movie Street Fighter: The Legend of Chun-Li, which opened in February 2009. She starred as Blair Williams in Terminator Salvation, the fourth film in the Terminator series and reprised her role in the video game and the prequel series of short film Terminator Salvation: The Machinima Series.
In early 2009, she joined the third season of the show Burn Notice in a recurring role as Detective Michelle Paxson.
From 2011 to 2015, she portrayed Dr. Anne Glass in TNT's science fiction series Falling Skies executive produced by Steven Spielberg. In 2012, Bloodgood won the "Special Jury Prize" for dramatic ensemble acting in The Sessions with John Hawkes, Helen Hunt, and William H. Macy.
She also voice acts the role of Uriel the Archangel in the video game Darksiders.
Bloodgood is married to Grady Hall. On December 15, 2012, Bloodgood gave birth to their first child, daughter Pepper. Their second child, Archie, was born on December 19, 2015.