Monroe is a surname of Scottish origin. Notable people with the surname include:
Alan H. Monroe (1903–1975), professor, creator of Monroe's motivated sequence
Alexander W. Monroe (1817–1905), American politician and Confederate States Army officer
Bill Monroe (1911–1996), American musician
Burt Monroe (1930–1994), American ornithologist
Christopher Monroe (born 1965), American physicist
Craig Monroe (born 1977), American MLB baseball player
Earl Monroe (born 1944), American Hall of Fame basketball player
Greg Monroe (born 1990) American professional basketball player
James Monroe (1758–1831), the 5th U.S. president
James Monroe (1799–1870), member of the U.S. House of Representatives and nephew of President Monroe
James T. Monroe, professor of Arabic and Comparative Literature
Jay R. Monroe, founder of the Monroe Calculator Company
Jordan Monroe (born 1986), American glamour model
Kristen Monroe (born 1946), American professor of Political Science
Marilyn Monroe (1926–1962), American actress
Mircea Monroe (born 1982), American actress
Nick Monroe (born 1982), American tennis player
Robert Monroe (1915–1995), author, founder of The Monroe Institute
Rodney Monroe (born 1968) American basketball player
Rodrick Monroe (born 1976), American football player
Vaughn Monroe (1911–1973), American baritone singer, trumpeter and big band leader