Symbol mir-663 miRBase family MIPF0000462 Domain(s) Eukaryota; | Rfam RF00957 RNA type microRNA | |
In molecular biology mir-663 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
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Gastric cancer suppression
miR-663 has been identified as a possible suppressor of tumour growth, with its levels downregulated in human gastric cancer (GC) cell lines. miR-663 introduction into the two human GC cell lines BGC823 and SNU5 induces morphology changes and suppresses cell proliferation. Transfection with miR-663 also sees a resultant upregulation of cyclin B.
miR-155 upregulation and other molecular targets
Resveratrol, a natural phenol and antioxidant, upregulates miR-663 in human THP-1 monocytic cells, human blood monocytes and MCF7 brest cancer cells. Endogenous activator protein-1 (AP-1) activity is decreased by miR-663 and there is additional impaired lipopolysaccharide upregulation. miR-663 directly targets JunD and JunB transcripts, and alters AP-1 upregulation through this. It is further involved in the impaired lipolysaccharide upregulation of miR-155 by resveratrol. miR-663 also directly targets EEF1A2, transaltion elongation factor and well-known protooncogene.