Symbol mir-650 miRBase family MIPF0000457 Domain(s) Eukaryota; | Rfam RF00952 RNA type microRNA | |
In molecular biology mir-650 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Contents
Diabetic and Non-Diabetic Heart Failure
miR-650 is one of a group of six miRNAs with altered expression levels in diabetic and non-diabetic heart failure. This altered expression corresponds to various enriched cardiac dysfunctions.
Chronic Lymphocytic Leukaemia
miR-650 has been found to be important in chronic lymphocytic leukaemia (CLL) and in normal B-lymphocyte physiology. It is associated with more favourable CLL prognoses when expressed at higher levels. In addition, it influences the proliferation capacity in B-cells through the targeting of proteins CDK1, ING4 and EBF3 (early B-cell factor 3).
NDRG2 regulation
miR-650 has further been reported to target a homologous DNA region in the promoter region of the NDRG2 gene. There is direct regulation of this gene at a transcriptional level, leading to repressed NDRG2 expression.