Bustos was born to Filipino parents in the Weston neighbourhood of Toronto. Before Canadian Idol, he worked as a temp at the Bank of Montreal. He attended St. Michael's College School in Toronto.
Bustos placed seventh runner-up in the finals of first season of Canadian Idol in August 2003, despite Chart magazine's prediction: "If we were to lay our bets today, ChartAttack’s money would be on Toronto contestant Mikey Bustos, a slightly strange-looking young man with a shaved head and the voice of an angel." From his very first audition where he floored the four judges, he established the largest fan base early in the competition, and made headlines all over the country.
Bustos recorded with BMG Music Canada and ViK. Recordings for the Canadian Idol compilation album, which was certified gold on the Soundscan Billboard charts on second day of release, and ranked in the Top 5 best selling Canadian albums in its debut week, selling over 60,000 units nationwide.
After competing on Canadian Idol, Bustos began performing throughout Canada and the US at many events and showcases at top venues. Mikey also had special guest appearances and interviews at numerous radio stations including CHUM FM, CFMT, Z 103.5 FM, Flow 93.5 FM, Mix 99.9 FM, AM 680 News, CHIN Ottawa FM, CKMS 100.3 FM Waterloo, and has several times appeared on CTV (Etalk Daily/ Canada AM Live), CBC Quebec, and local stations like Omni1 and Rogers (Daytime Toronto).
In 2004, Bustos recorded, performed, and mastered his craft in New York City residing in Queens and Manhattan, collaborating and recording with acclaimed producer Glenn Swan of the renowned Chung King Studios.
In 2005, Bustos released his debut extended play entitled Love Me Again on May 7. It was produced by Brent Bodrug of B-Group Music, who previously had worked with Alanis Morissette, Jack Soul, and Sugar Jones. It is available at all HMV locations across Canada.
In 2006, Bustos continued touring in the U.S. performing in New York, Chicago, Los Angeles, San Diego, and Las Vegas. He also began to perform in other countries, traveling to the Philippines, where he was front act for the Pussycat Dolls. Mikey also had a series of guest appearances, interviews, and live performances on popular Philippine TV shows including ABS-CBN's ASAP '06, and GMA-7's Eat Bulaga, StarTalk, SOP, S-Files, Unang Hirit, SIS, MTV Philippines, and even the country's first Philippine Idol. Mikey's radio performances and mall performance at Eastwood City in Manila were also highlights.
In 2007, Bustos was featured in a commercial for MTV Canada & was the front act for Christina Aguilera in the Philippines on July 6. He released a music video the next year for his single "If It Feels Good Then We Should" from his debut solo album Memoirs of a Superhero. The album was released on December 23, 2008, and its album art was designed by Orange Pop Media.
In 2009, Bustos' single "If It Feels Good Then We Should" reached Top 20 for multiple weeks on Canadian mainstream radio, as well as Top 2 Music Video on the California Music Channel in the US. His single "All I Need Is Me" was also played at Footlocker Stores nationwide. Under Bustos Entertainment Inc, he signed with Universal Music/North Fontana Distribution in May 2009.
In 2010, Bustos was nominated for a Toronto Independent Music Award for Best Adult Contemporary category. His song "Everytime My Heart Beats" from his debut album "Memoirs of a Superhero" since its release has become a YouTube phenomenon. Mikey was also involved in musical theater projects including a star role in the Summerworks production of Prison Dancer: The Musical.
Bustos continues to tour the world performing and making guest appearances on TV, radio, and the internet. In January 2014, Bustos joined the cast of the morning radio show Good Times with Mo on Magic 89.9 in the Philippines.
Bustos is also the owner of AntsCanada, an ant store based in Toronto that sells ant-keeping supplies made by Bustos in Manila.
In 2017, Bustos currently hosts his own TV show Mikey Bustos: Your Pinoy Boy which is currently aired on Philippine regional station CLTV 36 (based in Pampanga).
Bustos is known for his videos uploaded on video website YouTube. He made international headlines in March 2014 for his cover of Avicii's 'Wake Me Up' in which he performed an a cappella number with ten parts. Bustos is very open about his Filipinophilia, his popular videos cover a wide range of topics including "Filipinism", Philippine English phonology and Filipino culture tutorials such as eating Balut (duck embryo), Filipino dining, Filipino courting, and the Filipino CR. He also made a parody of "Born This Way" by Lady Gaga entitled "Pinoy This Way" and has many more based on various trending pop songs. He has appeared on television news several times: TV Patrol and Bandila on ABS-CBN; and 24 Oras and Saksi on GMA.
He also runs his other channel, AntsCanada, where he uploads videos about antkeeping. Mostly involving his personal colonies, and ant keeping tutorials. His most popular videos as of late 2016 document his ants trying to escape, and another of a live cockroach being eaten alive while giving birth.
In 2011, Bustos became the spokesperson and endorser for brands like Samsung, Nescafé, and the Mang Juan snacks. His TV commercials for Chicharron ni Mang Juan run on Philippine television on all major networks nationwide.