Midlands 2 East (South) is a level 7 English Rugby Union league and level 2 of the Midlands League, made up of teams from the southern part of the East Midlands region who play home and away matches throughout the season. The division was formed for the 2000-01 when the old Midlands 3 East was split into two regional divisions called Midlands 3 East (North) and Midlands 3 East (South) and gained its current title for the 2009-10 season due to further restructuring to the Midlands League. Promoted teams tend to move up to Midlands 1 East with the champions going up automatically and the runners up having to play a playoff against the runners up from Midlands 2 East (North) for their place. Demoted teams typically drop to Midlands 3 East (South).
Belgrave
Luton
Lutterworth
Market Harborough
Melton Mowbray
Oadby Wanderers
Oakham
Old Laurentians (relegated from Midlands 1 East)
Olney
Oundle (promoted from Midlands 3 East (South))
Peterborough
Rushden & Higham
Stamford (transferred from Midlands 2 East (North))
Vipers
Belgrave (relegated from Midlands 1 East)
Biggleswade
Leicester Forest
Lutterworth
Market Harborough
Melton Mowbray (promoted from Midlands 3 East (North))
Oadby Wanderers
Oakham
Olney
Peterborough
Rushden & Higham (promoted from Midlands 3 East (South))
Vipers (promoted from Midlands 3 East (South))
Biggleswade (promoted from Midlands 3 East (South))
Dunstablians
Leicester Forest
Lutterworth
Market Harborough
Northampton Old Scouts
Oadby Wyggestonians
Oakham
Olney
Peterborough (relegated from Midlands 1 East)
Stewarts & Lloyds (promoted from Midlands 3 East (South))
Wellingborough
Dunstablians
Leicester Forest
Leighton Buzzard
Lutterworth
Market Harborough
Newbold on Avon
Northampton BBOB
Northampton Old Scouts
Oadby Wyggestonians
Olney
Rushden & Higham (promoted from Midlands 3 East (South))
Wellingborough
Biggleswade (promoted from Midlands 3 East (South))
Bugbrooke
Dunstablians
Huntingdon & District
Leighton Buzzard (relegated from Midlands 1 East)
Lutterworth
Market Harborough
Northampton BBOB (promoted from Midlands 3 East (South))
Northampton Old Scouts
Oadby Wyggestonians
Vipers
Wellingborough
After leading the division from matchday 1, Huntingdon & District were pipped to the title by Bugbrooke by way of bonus points on the season's final day. Huntingdon were promoted alongside Bugbrooke to Midlands 1 East following a playoff victory over the second placed team from Midlands 2 East (North), Oakham. Biggleswade joined Vipers in the relegation places following a final day defeat to Oadby Wyggestonians.
Bugbrooke
Dunstablians
Huntingdon
Long Buckby
Lutterworth
Market Harborough
Northampton Old Scouts
Oadby Wygstonians
Peterborough Lions
Stockwood Park
Vipers
Wellingborough
Bugbrooke
Huntingdon and District
Leicester Forest
Lutterworth
Market Harborough
Northampton BBOB
Northampton Old Scouts
Peterborough Lions
Stewarts and Lloyds
Stockwood Park
Towcestrians
Vipers