Symbol miR-144 Rfam RF00682 miRBase family MIPF0000093 | Alt. Symbols MIR144 miRBase MI0000460 Entrez 406936 | |
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miR-144 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. In humans, miR-144 has been characterised as a "common miRNA signature" of a number of different tumours.
Contents
GATA4 is thought to activate transcription of the miR-144 microRNA precursor.
Function
miR-144 functions in a cluster with miR-451. This locus regulates the expression of a number of genes whose products are involved in erythropoiesis. One of the identified targets of miR-144 is insulin receptor substrate 1.
Applications
miR-144 has been identified as one of a number of potential miRNA targets which could be used to treat schizophrenia and bipolar affective disorder. It has also been suggested as a potential therapeutic tool to treat ischemic heart disease.