Harman Patil

Mezlocillin

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Pregnancy category  B
Protein binding  16–59%
Molar mass  539.584 g/mol
ATC code  J01CA10 (WHO)
Metabolism  Hepatic (20–30%)
CAS ID  51481-65-3
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AHFS/Drugs.com  Micromedex Detailed Consumer Information
Routes of administration  Intravenous, intramuscular

Mezlocillin sodium monohydrate uses reviews side effects and contraindications


Mezlocillin is a broad-spectrum penicillin antibiotic. It is active against both Gram-negative and some Gram-positive bacteria. Unlike most other extended spectrum penicillins, it is excreted by the liver, therefore it is useful for biliary tract infections, such as ascending cholangitis.

Contents

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Mechanism of action

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Like all other beta-lactam antibiotics, mezlocillin inhibits the third and last stage of bacterial cell wall synthesis by binding to penicillin binding proteins. This ultimately leads to cell lysis.

Synthesis

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Mezlocillin can be made in a variety of ways including reaction of ampicillin with chlorocarbamate 1 in the presence of triethylamine. Chlorocarbamate 1 itself is made from ethylenediamine by reaction with phosgene to form the cyclic urea followed by monoamide formation with methanesulfonyl chloride and then reaction of the other nitrogen atom with phosgene and trimethylsilylchloride.

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The closely related analogue azlocillin is made in essentially the same manner as mezlocillin. but with omission of the methylation step.

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References

Mezlocillin Wikipedia


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